Ontology highlight
ABSTRACT:
SUBMITTER: Imam T
PROVIDER: S-EPMC5992276 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Imam Tanbeena T Park Sungtae S Kaplan Mark H MH Olson Matthew R MR
Frontiers in immunology 20180601
The gastrointestinal tract is a site of high immune challenge, as it must maintain a delicate balance between tolerating luminal contents and generating an immune response toward pathogens. CD4<sup>+</sup> T cells are key in mediating the host protective and homeostatic responses. Yet, CD4<sup>+</sup> T cells are also known to be the main drivers of inflammatory bowel disease (IBD) when this balance is perturbed. Many subsets of CD4<sup>+</sup> T cells have been identified as players in perpetua ...[more]