Ontology highlight
ABSTRACT:
SUBMITTER: Onischenko E
PROVIDER: S-EPMC5992322 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Onischenko Evgeny E Tang Jeffrey H JH Andersen Kasper R KR Knockenhauer Kevin E KE Vallotton Pascal P Derrer Carina P CP Kralt Annemarie A Mugler Christopher F CF Chan Leon Y LY Schwartz Thomas U TU Weis Karsten K
Cell 20171012 4
Nuclear pore complexes (NPCs) are ∼100 MDa transport channels assembled from multiple copies of ∼30 nucleoporins (Nups). One-third of these Nups contain phenylalanine-glycine (FG)-rich repeats, forming a diffusion barrier, which is selectively permeable for nuclear transport receptors that interact with these repeats. Here, we identify an additional function of FG repeats in the structure and biogenesis of the yeast NPC. We demonstrate that GLFG-containing FG repeats directly bind to multiple sc ...[more]