Ontology highlight
ABSTRACT:
SUBMITTER: Spadaro O
PROVIDER: S-EPMC5992590 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Spadaro Olga O Goldberg Emily L EL Camell Christina D CD Youm Yun-Hee YH Kopchick John J JJ Nguyen Kim Y KY Bartke Andrzej A Sun Liou Y LY Dixit Vishwa Deep VD
Cell reports 20160211 7
The hallmarks of age-related immune senescence are chronic inflammation, aberrant expansion of effector memory, and loss of naive T lymphocytes due in part to systemic activation of innate immune sensor NLRP3 inflammasome in myeloid lineage cells. The endogenous mechanisms that regulate inflammasome activation during aging are unknown. Here, we present evidence that growth hormone receptor (GH-R)-dependent downregulation of NLRP3 inflammasome in macrophages is linked to pro-longevity effects tha ...[more]