Ontology highlight
ABSTRACT:
SUBMITTER: Gelb S
PROVIDER: S-EPMC5994369 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Gelb Sivan S Stock Ariel D AD Anzi Shira S Putterman Chaim C Ben-Zvi Ayal A
Journal of autoimmunity 20180404
The pathogenesis of neuropsychiatric lupus (NPSLE) is believed to include the entry of circulating neuropathic antibodies to the brain via a pathologically permeable blood-brain barrier (BBB). Nevertheless, direct evidence of BBB pathology or mechanisms underlying BBB dysfunction is missing. Here, we examined BBB integrity in an established NPSLE mouse model (MRL/fas<sup>lpr/lpr</sup>). Surprisingly, challenging the barrier with various exogenous tracers demonstrated insignificant changes in BBB ...[more]