Ontology highlight
ABSTRACT:
SUBMITTER: Verscheijden LFM
PROVIDER: S-EPMC7502061 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Verscheijden L F M LFM van Hattem A C AC Pertijs J C L M JCLM de Jongh C A CA Verdijk R M RM Smeets B B Koenderink J B JB Russel F G M FGM de Wildt S N SN
Histochemistry and cell biology 20200524 3
When drugs exert their effects in the brain, linear extrapolation of doses from adults could be harmful for children as the blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) function is still immature. More specifically, age-related variation in membrane transporters may impact brain disposition. As human data on brain transporter expression is scarce, age dependent [gestational age (GA), postnatal age (PNA), and postmenstrual age (PMA)] variation in immunohistochemical localization and st ...[more]