Ontology highlight
ABSTRACT:
SUBMITTER: Crack JC
PROVIDER: S-EPMC5994877 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Crack Jason C JC Hamilton Chris J CJ Le Brun Nick E NE
Chemical communications (Cambridge, England) 20180601 47
The bacterial nitric oxide (NO)-sensing transcriptional regulator NsrR binds a [4Fe-4S] cluster that enables DNA-binding and thus repression of the cell's NO stress response. Upon exposure to NO, the cluster undergoes a complex nitrosylation reaction resulting in a mixture of iron-nitrosyl species, which spectroscopic studies have indicated are similar to well characterized low molecular weight dinitrosyl iron complex (DNIC), Roussin's Red Ester (RRE) and Roussin's Black Salt (RBS). Here we repo ...[more]