Ca²⁺-activated Cl^- current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization.

ABSTRACT: The role of Ca²⁺-activated Cl^- current (I_Cl(Ca)) in cardiac arrhythmias is still controversial. It can generate delayed afterdepolarizations in Ca²⁺-overloaded cells while in other studies incidence of early afterdepolarization (EAD) was reduced by I_Cl(Ca). Therefore our goal was to examine the role of I_Cl(Ca) in spatial and temporal heterogeneity of cardiac repolarization and EAD formation. Experiments were performed on isolated canine cardiomyocytes originating from various regions of the left ventricle; subepicardial, midmyocardial and subendocardial cells, as well as apical and basal cells of the midmyocardium. I_Cl(Ca) was blocked by 0.5mmol/L 9-anthracene carboxylic acid (9-AC). Action potential (AP) changes

SUBMITTER: Hegyi B 

PROVIDER: S-EPMC5995131 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature