Epigenetic dysregulation of TET2 in human glioblastoma.
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ABSTRACT:
SUBMITTER: Garcia MG
PROVIDER: S-EPMC5995234 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Epigenetic dysregulation of <i>TET2</i> in human glioblastoma.
García María G MG Carella Antonella A Urdinguio Rocío G RG Bayón Gustavo F GF Lopez Virginia V Tejedor Juan Ramón JR Sierra Marta I MI García-Toraño Estela E Santamarina Pablo P Perez Raúl F RF Mangas Cristina C Astudillo Aurora A Corte-Torres M Daniela MD Sáenz-de-Santa-María Inés I Chiara María-Dolores MD Fernández Agustín F AF Fraga Mario F MF
Oncotarget 20180525 40
Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that <i>TET2</i> shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well as loss of histone acetylation. Ectopic overexpression of <i>TET2</i> regulated neural differentiation in glioblastoma cell lines and impaired tumor growth. Our results suggest that epigenetic d ...[more]
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