Ontology highlight
ABSTRACT:
SUBMITTER: Pasque V
PROVIDER: S-EPMC5995367 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Pasque Vincent V Karnik Rahul R Chronis Constantinos C Petrella Paula P Langerman Justin J Bonora Giancarlo G Song Juan J Vanheer Lotte L Sadhu Dimashkie Anupama A Meissner Alexander A Plath Kathrin K
Stem cell reports 20180419 5
A dramatic difference in global DNA methylation between male and female cells characterizes mouse embryonic stem cells (ESCs), unlike somatic cells. We analyzed DNA methylation changes during reprogramming of male and female somatic cells and in resulting induced pluripotent stem cells (iPSCs). At an intermediate reprogramming stage, somatic and pluripotency enhancers are targeted for partial methylation and demethylation. Demethylation within pluripotency enhancers often occurs at ESC binding s ...[more]