Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Mariscal A
PROVIDER: S-EPMC5997168 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Small GTPases 20161116 5
The ubiquitously expressed small GTPase RhoA is essential for embryonic development and mutated in different cancers. Functionally, it is well described as a regulator of the actin cytoskeleton, but its role in gene regulation is less understood. Using primary mouse keratinocytes with a deletion of the RhoA gene, we have now been exploring how the loss of RhoA affects gene expression. Performing transcription factor reporter assays, we found a significantly decreased activity of a RAR luciferase ...[more]