Ontology highlight
ABSTRACT:
SUBMITTER: Bryan BA
PROVIDER: S-EPMC2923346 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100416 9
The small GTPase RhoA and its downstream effectors, ROCK1 and ROCK2, regulate a number of cellular processes, including cell motility, proliferation, survival, and permeability. Pharmacological inhibitors of the Rho pathway reportedly block angiogenesis; however, the molecular details of this inhibition are largely unknown. We demonstrate that vascular endothelial growth factor-A (VEGF) rapidly induces RhoA activation in endothelial cells (ECs). Moreover, the pharmacological inhibition of ROCK1/ ...[more]