Ontology highlight
ABSTRACT:
SUBMITTER: Marton L
PROVIDER: S-EPMC5997628 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Marton Lívia L Hajdú Fanni F Nagy Gergely N GN Kucsma Nóra N Szakács Gergely G Vértessy Beáta G BG
Scientific reports 20180612 1
The plasmodial CTP:phosphocholine cytidylyltransferase (PfCCT) is a promising antimalarial target, which can be inhibited to exploit the need for increased lipid biosynthesis during the erythrocytic life stage of Plasmodium falciparum. Notable structural and regulatory differences of plasmodial and mammalian CCTs offer the possibility to develop species-specific inhibitors. The aim of this study was to use CHO-MT58 cells expressing a temperature-sensitive mutant CCT for the functional characteri ...[more]