Risk stratification of smoldering multiple myeloma incorporating revised IMWG diagnostic criteria.

ABSTRACT: In 2014, the International Myeloma Working Group reclassified patients with smoldering multiple myeloma (SMM) and bone marrow-plasma cell percentage (BMPC%)???60%, or serum free light chain ratio (FLCr)???100 or >1 focal lesion on magnetic resonance imaging as multiple myeloma (MM). Predictors of progression in patients currently classified as SMM are not known. We identified 421 patients with SMM, diagnosed between 2003 and 2015. The median time to progression (TTP) was 57 months (CI, 45-72). BMPC% >?20% [hazard ratio (HR): 2.28 (CI, 1.63-3.20); p??2g/dL [HR: 1.56 (CI, 1.11-2.20); p?=?0.01], and FLCr >?20 [HR: 2.13 (CI, 1.55-2.93); p??20%, M-protein?>?2?g/dL, and FLCr?>?20 at diagnosis can be used to risk stratify patients with SMM. Patients with high-risk SMM need close follow-up and are candidates for clinical trials aiming to prevent progression.

SUBMITTER: Lakshman A 

PROVIDER: S-EPMC5997745 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature