Ontology highlight
ABSTRACT:
SUBMITTER: Hwang I
PROVIDER: S-EPMC5998560 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Hwang Inah I Cao Dongqing D Na Yoonmi Y Kim Do-Yeon DY Zhang Tuo T Yao Jun J Oh Hwanhee H Hu Jian J Zheng Hongwu H Yao Yu Y Paik Jihye J
Stem cell reports 20180329 4
Loss of a cell's ability to terminally differentiate because of mutations is a selected genetic event in tumorigenesis. Genomic analyses of low-grade glioma have reported recurrent mutations of far upstream element-binding protein 1 (FUBP1). Here, we show that FUBP1 expression is dynamically regulated during neurogenesis and that its downregulation in neural progenitors impairs terminal differentiation and promotes tumorigenesis collaboratively with expression of IDH1<sup>R132H</sup>. Mechanisti ...[more]