Ontology highlight
ABSTRACT:
SUBMITTER: Dumenieu M
PROVIDER: S-EPMC5998957 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Dumenieu Mael M Senkov Oleg O Mironov Andrey A Bourinet Emmanuel E Kreutz Michael R MR Dityatev Alexander A Heine Martin M Bikbaev Arthur A Lopez-Rojas Jeffrey J
Cerebral cortex (New York, N.Y. : 1991) 20180701 7
Mature granule cells are poorly excitable neurons that were recently shown to fire action potentials, preferentially in bursts. It is believed that the particularly pronounced short-term facilitation of mossy fiber synapses makes granule cell bursting a very effective means of properly transferring information to CA3. However, the mechanism underlying the unique bursting behavior of mature granule cells is currently unknown. Here, we show that Cav3.2 T-type channels at the axon initial segment a ...[more]