Ontology highlight
ABSTRACT:
SUBMITTER: Candelas M
PROVIDER: S-EPMC6395820 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Candelas Miriam M Reynders Ana A Arango-Lievano Margarita M Neumayer Christoph C Fruquière Antoine A Demes Elsa E Hamid Jawed J Lemmers Céline C Bernat Claire C Monteil Arnaud A Compan Vincent V Laffray Sophie S Inquimbert Perrine P Le Feuvre Yves Y Zamponi Gerald W GW Moqrich Aziz A Bourinet Emmanuel E Méry Pierre-François PF
Scientific reports 20190228 1
The T-type calcium channel, Cav3.2, is necessary for acute pain perception, as well as mechanical and cold allodynia in mice. Being found throughout sensory pathways, from excitatory primary afferent neurons up to pain matrix structures, it is a promising target for analgesics. In our study, Cav3.2 was detected in ~60% of the lamina II (LII) neurons of the spinal cord, a site for integration of sensory processing. It was co-expressed with Tlx3 and Pax2, markers of excitatory and inhibitory inter ...[more]