Irreversible temperature gating in trpv1 sheds light on channel activation.
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ABSTRACT:
SUBMITTER: Sanchez-Moreno A
PROVIDER: S-EPMC5999395 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Irreversible temperature gating in trpv1 sheds light on channel activation.
Sánchez-Moreno Ana A Guevara-Hernández Eduardo E Contreras-Cervera Ricardo R Rangel-Yescas Gisela G Ladrón-de-Guevara Ernesto E Rosenbaum Tamara T Islas León D LD
eLife 20180605
Temperature-activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We have carefully characterized the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 chann ...[more]
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