Directed nickel-catalyzed 1,2-dialkylation of alkenyl carbonyl compounds.

ABSTRACT: A nickel-catalyzed conjunctive cross-coupling of non-conjugated alkenes, alkyl halides, and alkylzinc reagents is reported. Regioselectivity is controlled by chelation of a removable bidentate 8-aminoquinoline directing group. Under optimized conditions, a wide range of 1,2-dialkylated products can be accessed in moderate to excellent yields. To the best of our knowledge, this report represents the first example of three-component 1,2-dialkylation of non-conjugated alkenes to introduce differentiated alkyl fragments.

SUBMITTER: Derosa J 

PROVIDER: S-EPMC6001383 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature