Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez LW
PROVIDER: S-EPMC5971658 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Hernandez Lucas W LW Klöckner Ulrich U Pospech Jola J Hauss Lilian L Sarlah David D
Journal of the American Chemical Society 20180323 13
We describe the development of an arenophile-mediated, nickel-catalyzed dearomative trans-1,2-carboamination protocol. A range of readily available aromatic compounds was converted to the corresponding dienes using Grignard reagents as nucleophiles. This strategy provided products with exclusive trans-selectivity and high enantioselectivity was observed in case of benzene and naphthalene. The utility of this methodology was showcased by controlled and stereoselective preparation of small, functi ...[more]