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Using 2 H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE.

ABSTRACT: By introducing a range of 2 H labels into pyridine and the para-substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T1 relaxation for the remaining 1 H nuclei are increased and show how this leads to a concomitant increase in the level of 1 H and 13 C hyperpolarization that can ultimately be detected.

SUBMITTER: Norcott P 

PROVIDER: S-EPMC6001449 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Using <sup>2</sup> H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE.

Norcott Philip P   Burns Michael J MJ   Rayner Peter J PJ   Mewis Ryan E RE   Duckett Simon B SB  

Magnetic resonance in chemistry : MRC 20180125 7

By introducing a range of <sup>2</sup> H labels into pyridine and the para-substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T<sub>1</sub> relaxation for the remaining <sup>1</sup> H nuclei are increased and show how this leads to a concomitant increase in the level of <sup>1</sup> H and <sup>13</sup> C hyperpolarization that can u  ...[more]

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