Ontology highlight
ABSTRACT:
SUBMITTER: Fekete M
PROVIDER: S-EPMC7277555 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Fekete Marianna M Ahwal Fadi F Duckett Simon B SB
The journal of physical chemistry. B 20200526 22
While many drugs and metabolites contain nitrogen, harnessing their diagnostic <sup>15</sup>N NMR signature for their characterization is underutilized because of inherent detection difficulties. Here, we demonstrate how precise ultralow field signal amplification by reversible exchange (±0.2 mG) in conjunction <i>para</i>hydrogen and an iridium precatalyst of the form IrCl(COD)(NHC) with the coligand <i>d</i><sub>9</sub>-benzylamine allows the naturally abundant <sup>15</sup>N NMR signatures of ...[more]