Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Fuentes MP
PROVIDER: S-EPMC6001640 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Hernandez-Fuentes Maria P MP Franklin Christopher C Rebollo-Mesa Irene I Mollon Jennifer J Delaney Florence F Perucha Esperanza E Stapleton Caragh C Borrows Richard R Byrne Catherine C Cavalleri Gianpiero G Clarke Brendan B Clatworthy Menna M Feehally John J Fuggle Susan S Gagliano Sarah A SA Griffin Sian S Hammad Abdul A Higgins Robert R Jardine Alan A Keogan Mary M Leach Timothy T MacPhee Iain I Mark Patrick B PB Marsh James J Maxwell Peter P McKane William W McLean Adam A Newstead Charles C Augustine Titus T Phelan Paul P Powis Steve S Rowe Peter P Sheerin Neil N Solomon Ellen E Stephens Henry H Thuraisingham Raj R Trembath Richard R Topham Peter P Vaughan Robert R Sacks Steven H SH Conlon Peter P Opelz Gerhard G Soranzo Nicole N Weale Michael E ME Lord Graham M GM
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20180201 6
Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining p ...[more]