Ontology highlight
ABSTRACT:
SUBMITTER: Setliff I
PROVIDER: S-EPMC6002606 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Setliff Ian I McDonnell Wyatt J WJ Raju Nagarajan N Bombardi Robin G RG Murji Amyn A AA Scheepers Cathrine C Ziki Rutendo R Mynhardt Charissa C Shepherd Bryan E BE Mamchak Alusha A AA Garrett Nigel N Karim Salim Abdool SA Mallal Simon A SA Crowe James E JE Morris Lynn L Georgiev Ivelin S IS
Cell host & microbe 20180531 6
Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an infection-naive state through acute and chronic infection using next-generation sequencing. This analysis revealed the existence of "public" antibody clonotypes that were shared am ...[more]