Ontology highlight
ABSTRACT:
SUBMITTER: Cameron BJ
PROVIDER: S-EPMC6002776 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Cameron Brian J BJ Gerry Andrew B AB Dukes Joseph J Harper Jane V JV Kannan Vivekanandan V Bianchi Frayne C FC Grand Francis F Brewer Joanna E JE Gupta Minnal M Plesa Gabriela G Bossi Giovanna G Vuidepot Annelise A Powlesland Alex S AS Legg Alison A Adams Katherine J KJ Bennett Alan D AD Pumphrey Nicholas J NJ Williams Daniel D DD Binder-Scholl Gwendolyn G Kulikovskaya Irina I Levine Bruce L BL Riley James L JL Varela-Rohena Angel A Stadtmauer Edward A EA Rapoport Aaron P AP Linette Gerald P GP June Carl H CH Hassan Namir J NJ Kalos Michael M Jakobsen Bent K BK
Science translational medicine 20130801 197
MAGE A3, which belongs to the family of cancer-testis antigens, is an attractive target for adoptive therapy given its reactivation in various tumors and limited expression in normal tissues. We developed an affinity-enhanced T cell receptor (TCR) directed to a human leukocyte antigen (HLA)-A*01-restricted MAGE A3 antigen (EVDPIGHLY) for use in adoptive therapy. Extensive preclinical investigations revealed no off-target antigen recognition concerns; nonetheless, administration to patients of T ...[more]