Dataset Information

Risk factors for poor outcome in community-onset Clostridium difficile infection.

ABSTRACT:

Background

A substantial portion of Clostridium difficile infection (CDI) cases occur in communities, and community-onset CDI (CO-CDI) can lead to serious complications including mortality. This study aimed to identify the risk factors for a poor outcome in CO-CDI.

Methods

We performed a retrospective review of all inpatients with CDI, in a 1300-bed tertiary-care hospital in Korea, from 2008 through 2015. CO-CDI was defined as CDI occurring within 48 h of admission. Poor outcome was defined as follows: 1) all-cause 30-day mortality, 2) in-hospital mortality, or 3) surgery due to CDI.

Results

Of a total 1256 CDIs occurring over 8 years, 152 (12.1%) cases were classified as CO-CDI and 23 (15.1%) had a poor outcome, including 22 (14.5%) cases of mortality and 2 (1.3%) cases of surgery. Patients with a poor outcome had a higher mean age than those without a poor outcome (75.8 vs. 69.6 years, p?=?0.03). The proportion of men and prior proton pump inhibitor (PPI) use were significantly higher in the poor outcome group (65.2% vs. 41.9%, p?=?0.04; 39.1% vs. 17.6%, p?=?0.02, respectively). Multivariate binary logistic model showed that PPI use and anemia (hemoglobin ConclusionsClinicians should not only be aware of the possibility of CDI in the community setting but also pay more attention to PPI-using elderly patients with anemia in consideration of a poor outcome.

SUBMITTER: Lee E

PROVIDER: S-EPMC6003152 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Risk factors for poor outcome in community-onset <i>Clostridium difficile</i> infection.

Lee Eunyoung E Song Kyoung-Ho KH Bae Ji Yun JY Yoon Doran D Hwang Joo-Hee JH Choe Pyoeng Gyun PG Park Wan Beom WB Bang Ji Hwan JH Kim Eu Suk ES Park Sang Won SW Kim Nam Joong NJ Oh Myoung-Don MD Kim Hong Bin HB

Antimicrobial resistance and infection control 20180615

<h4>Background</h4>A substantial portion of <i>Clostridium difficile</i> infection (CDI) cases occur in communities, and community-onset CDI (CO-CDI) can lead to serious complications including mortality. This study aimed to identify the risk factors for a poor outcome in CO-CDI.<h4>Methods</h4>We performed a retrospective review of all inpatients with CDI, in a 1300-bed tertiary-care hospital in Korea, from 2008 through 2015. CO-CDI was defined as CDI occurring within 48 h of admission. Poor ou ...[more]

PMID: 29946450

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