Dataset Information

Association of Community Factors with Hospital-onset Clostridioides (Clostridium) difficile Infection: A Population Based U.S.-wide Study.

ABSTRACT:

Background

Clostridioides (Clostridium) difficile ranks first among the pathogens of hospital-acquired infections with hospital-based preventive strategies being only partially successful in containing its spread.

Methods

We performed a spatial statistical analysis to examine the association between population characteristics and parameters of community healthcare practice and delivery with hospital-onset Clostridioides (Clostridium) difficile infection (HO-CDI), using data from the Medicare Hospital Compare, Medicare Provider Utilization Part D, and other databases. Among the areas with the highest HO-CDI rates ("hot spots"), we conducted a geographically weighted regression (GWR) to quantify the effect of the decrease in the modifiable risk factors on the HO-CDI rate.

Findings

Percentage of population?>?85?years old, community claims of antimicrobial agents and acid suppressants, and density of hospitals and nursing homes within the hospital service areas (HSAs) had a statistically significant association with the HO-CDI incidence (p?2 was associated with 10% (R²?=?0.10, p?2?=?0.71, SD 0.19), with a 10% decrease in the rate of antimicrobial claims having the potential to lead to up to 23.1% decrease in the HO-CDI incidence in this area.

Interpretation

These results outline the association of HO-CDI with community practice and characteristics of the healthcare delivery system and support the need to further study the effect of community and nursing home-based antimicrobial and acid suppressant stewardship programs in the rate of HO-CDI in geographic areas that may cross state lines.

SUBMITTER: Zacharioudakis IM

PROVIDER: S-EPMC6537581 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Publications

Association of Community Factors with Hospital-onset <i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile</i> Infection: A Population Based U.S.-wide Study.

Zacharioudakis Ioannis M IM Zervou Fainareti N FN Shehadeh Fadi F Mylona Evangelia K EK Mylonakis Eleftherios E

EClinicalMedicine 20190219

<h4>Background</h4><i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile</i> ranks first among the pathogens of hospital-acquired infections with hospital-based preventive strategies being only partially successful in containing its spread.<h4>Methods</h4>We performed a spatial statistical analysis to examine the association between population characteristics and parameters of community healthcare practice and delivery with hospital-onset <i>Clostridioides</i> (<i>Clostridium</i>) <i>difficile ...[more]

PMID: 31193719

Similar Datasets

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