Ontology highlight
ABSTRACT:
SUBMITTER: Toleman CA
PROVIDER: S-EPMC6003352 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Toleman Clifford A CA Schumacher Maria A MA Yu Seok-Ho SH Zeng Wenjie W Cox Nathan J NJ Smith Timothy J TJ Soderblom Erik J EJ Wands Amberlyn M AM Kohler Jennifer J JJ Boyce Michael M
Proceedings of the National Academy of Sciences of the United States of America 20180521 23
O-GlcNAc is an intracellular posttranslational modification that governs myriad cell biological processes and is dysregulated in human diseases. Despite this broad pathophysiological significance, the biochemical effects of most O-GlcNAcylation events remain uncharacterized. One prevalent hypothesis is that O-GlcNAc moieties may be recognized by "reader" proteins to effect downstream signaling. However, no general O-GlcNAc readers have been identified, leaving a considerable gap in the field. To ...[more]