Ontology highlight
ABSTRACT:
SUBMITTER: Ball NJ
PROVIDER: S-EPMC3488213 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Ball N J NJ McGeehan J E JE Streeter S D SD Thresh S-J SJ Kneale G G GG
Nucleic acids research 20120831 20
Controller (C) proteins regulate the expression of restriction-modification (RM) genes in a wide variety of RM systems. However, the RM system Esp1396I is of particular interest as the C protein regulates both the restriction endonuclease (R) gene and the methyltransferase (M) gene. The mechanism of this finely tuned genetic switch depends on differential binding affinities for the promoters controlling the R and M genes, which in turn depends on differential DNA sequence recognition and the abi ...[more]