Ontology highlight
ABSTRACT:
SUBMITTER: Tzeng SY
PROVIDER: S-EPMC6003376 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Tzeng Stephany Y SY McHugh Kevin J KJ Behrens Adam M AM Rose Sviatlana S Sugarman James L JL Ferber Shiran S Langer Robert R Jaklenec Ana A
Proceedings of the National Academy of Sciences of the United States of America 20180521 23
Vaccination in the developing world is hampered by limited patient access, which prevents individuals from receiving the multiple injections necessary for protective immunity. Here, we developed an injectable microparticle formulation of the inactivated polio vaccine (IPV) that releases multiple pulses of stable antigen over time. To accomplish this, we established an IPV stabilization strategy using cationic polymers for pH modulation to enhance traditional small-molecule-based stabilization me ...[more]