Ontology highlight
ABSTRACT:
SUBMITTER: Labro AJ
PROVIDER: S-EPMC6003467 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Labro Alain J AJ Cortes D Marien DM Tilegenova Cholpon C Cuello Luis G LG
Proceedings of the National Academy of Sciences of the United States of America 20180507 21
The selectivity filter and the activation gate in potassium channels are functionally and structurally coupled. An allosteric coupling underlies C-type inactivation coupled to activation gating in this ion-channel family (i.e., opening of the activation gate triggers the collapse of the channel's selectivity filter). We have identified the second Threonine residue within the TTVGYGD signature sequence of K<sup>+</sup> channels as a crucial residue for this allosteric communication. A Threonine t ...[more]