Ontology highlight
ABSTRACT:
SUBMITTER: Yang Q
PROVIDER: S-EPMC6755126 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Yang Qian Q Yu Chien-Hung CH Zhao Fangzhou F Dang Yunkun Y Wu Cheng C Xie Pancheng P Sachs Matthew S MS Liu Yi Y
Nucleic acids research 20190901 17
Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and plays an important role in regulating gene expression levels. A major role of codon usage is thought to regulate protein expression levels by affecting mRNA translation efficiency, but the underlying mechanism is unclear. By analyzing ribosome profiling results, here we showed that codon usage regulates translation elongation rate and that rare codons are decoded more slowly than common codons in all codon families ...[more]