Ontology highlight
ABSTRACT:
SUBMITTER: Pakharukova N
PROVIDER: S-EPMC6003481 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20180507 21
<i>Acinetobacter baumannii</i>-a leading cause of nosocomial infections-has a remarkable capacity to persist in hospital environments and medical devices due to its ability to form biofilms. Biofilm formation is mediated by Csu pili, assembled via the "archaic" chaperone-usher pathway. The X-ray structure of the CsuC-CsuE chaperone-adhesin preassembly complex reveals the basis for bacterial attachment to abiotic surfaces. CsuE exposes three hydrophobic finger-like loops at the tip of the pilus. ...[more]