Ontology highlight
ABSTRACT:
SUBMITTER: Niture S
PROVIDER: S-EPMC6003558 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Niture Suryakant S Ramalinga Malathi M Kedir Habib H Patacsil Dorrelyn D Niture Samiksha S SS Li James J Mani Haresh H Suy Simeng S Collins Sean S Kumar Deepak D
Oncotarget 20180601 42
Tumor necrosis factor-α-inducible protein 8 (TNFAIP8) is a TNF-α inducible anti-apoptotic protein with multiple roles in tumor growth and survival. Mechanisms of cell survival by TNFAIP8 remain elusive. We investigated the role of TNFAIP8 in the regulation of the cell cycle, autophagy, cell survival and neuroendocrine differentiation in prostate cancer cells. We showed that TNFAIP8 dysregulates cell-cycle-related proteins, in PC3 cells. Oncogenic cell survival, drug resistance and dysregulation ...[more]