Ontology highlight
ABSTRACT:
SUBMITTER: Niture S
PROVIDER: S-EPMC7062894 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Niture Suryakant S Gyamfi Maxwell A MA Lin Minghui M Chimeh Uchechukwu U Dong Xialan X Zheng Weifan W Moore John J Kumar Deepak D
Cell death & disease 20200309 3
Tumor necrosis factor-α-induced protein 8 (TNFAIP8) expression has been linked to tumor progression in various cancer types, but the detailed mechanisms of TNFAIP8 are not fully elucidated. Here we define the role of TNFAIP8 in early events associated with development of hepatocellular carcinoma (HCC). Increased TNFAIP8 levels in HCC cells enhanced cell survival by blocking apoptosis, rendering HCC cells more resistant to the anticancer drugs, sorafenib and regorafenib. TNFAIP8 also induced auto ...[more]