Ontology highlight
ABSTRACT:
SUBMITTER: Dorn T
PROVIDER: S-EPMC6003642 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Dorn Tatjana T Kornherr Jessica J Parrotta Elvira I EI Zawada Dorota D Ayetey Harold H Santamaria Gianluca G Iop Laura L Mastantuono Elisa E Sinnecker Daniel D Goedel Alexander A Dirschinger Ralf J RJ My Ilaria I Laue Svenja S Bozoglu Tarik T Baarlink Christian C Ziegler Tilman T Graf Elisabeth E Hinkel Rabea R Cuda Giovanni G Kääb Stefan S Grace Andrew A AA Grosse Robert R Kupatt Christian C Kupatt Christian C Meitinger Thomas T Smith Austin G AG Laugwitz Karl-Ludwig KL Moretti Alessandra A
The EMBO journal 20180515 12
Cell-cell and cell-matrix interactions guide organ development and homeostasis by controlling lineage specification and maintenance, but the underlying molecular principles are largely unknown. Here, we show that in human developing cardiomyocytes cell-cell contacts at the intercalated disk connect to remodeling of the actin cytoskeleton by regulating the RhoA-ROCK signaling to maintain an active MRTF/SRF transcriptional program essential for cardiomyocyte identity. Genetic perturbation of this ...[more]