Dataset Information

A Fine-Scale Functional Logic to Convergence from Retina to Thalamus.

ABSTRACT: Numerous well-defined classes of retinal ganglion cells innervate the thalamus to guide image-forming vision, yet the rules governing their convergence and divergence remain unknown. Using two-photon calcium imaging in awake mouse thalamus, we observed a functional arrangement of retinal ganglion cell axonal boutons in which coarse-scale retinotopic ordering gives way to fine-scale organization based on shared preferences for other visual features. Specifically, at the ?6 ?m scale, clusters of boutons from different axons often showed similar preferences for either one or multiple features, including axis and direction of motion, spatial frequency, and changes in luminance. Conversely, individual axons could "de-multiplex" information channels by participating in multiple, functionally distinct bouton clusters. Finally, ultrastructural analyses demonstrated that retinal axonal boutons in a local cluster often target the same dendritic domain. These data suggest that functionally specific convergence and divergence of retinal axons may impart diverse, robust, and often novel feature selectivity to visual thalamus.

SUBMITTER: Liang L

PROVIDER: S-EPMC6003778 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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A Fine-Scale Functional Logic to Convergence from Retina to Thalamus.

Liang Liang L Fratzl Alex A Goldey Glenn G Ramesh Rohan N RN Sugden Arthur U AU Morgan Josh L JL Chen Chinfei C Andermann Mark L ML

Cell 20180531 6

Numerous well-defined classes of retinal ganglion cells innervate the thalamus to guide image-forming vision, yet the rules governing their convergence and divergence remain unknown. Using two-photon calcium imaging in awake mouse thalamus, we observed a functional arrangement of retinal ganglion cell axonal boutons in which coarse-scale retinotopic ordering gives way to fine-scale organization based on shared preferences for other visual features. Specifically, at the ∼6 μm scale, clusters of b ...[more]

PMID: 29856953

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Dataset Information

A Fine-Scale Functional Logic to Convergence from Retina to Thalamus.

Publications

A Fine-Scale Functional Logic to Convergence from Retina to Thalamus.

Similar Datasets

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