Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis.
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ABSTRACT:
SUBMITTER: Fehr AR
PROVIDER: S-EPMC6003825 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis.
Fehr Anthony R AR Jankevicius Gytis G Ahel Ivan I Perlman Stanley S
Trends in microbiology 20180701 7
Viruses from the Coronaviridae, Togaviridae, and Hepeviridae families all contain genes that encode a conserved protein domain, called a macrodomain; however, the role of this domain during infection has remained enigmatic. The recent discovery that mammalian macrodomain proteins enzymatically remove ADP-ribose, a common post-translation modification, from proteins has led to an outburst of studies describing both the enzymatic activity and function of viral macrodomains. These new studies have ...[more]
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