Ontology highlight
ABSTRACT:
SUBMITTER: Goodwin E
PROVIDER: S-EPMC6005179 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Goodwin Eileen E Gilman Morgan S A MSA Wrapp Daniel D Chen Man M Ngwuta Joan O JO Moin Syed M SM Bai Patricia P Sivasubramanian Arvind A Connor Ruth I RI Wright Peter F PF Graham Barney S BS McLellan Jason S JS Walker Laura M LM
Immunity 20180203 2
Respiratory syncytial virus (RSV) is a leading cause of infant mortality, and there are currently no licensed vaccines to protect this vulnerable population. A comprehensive understanding of infant antibody responses to natural RSV infection would facilitate vaccine development. Here, we isolated more than 450 RSV fusion glycoprotein (F)-specific antibodies from 7 RSV-infected infants and found that half of the antibodies recognized only two antigenic sites. Antibodies targeting both sites showe ...[more]