Ontology highlight
ABSTRACT:
SUBMITTER: Maji A
PROVIDER: S-EPMC6005269 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Maji Arun A Bhaskararao Bangaru B Singha Santanu S Sunoj Raghavan B RB Maiti Debabrata D
Chemical science 20160121 5
<i>meta</i>-Hydroxylated cores are ubiquitous in natural products. Herein, we disclose the first template assisted <i>meta-</i>hydroxylation reaction. Experimental and <i>in silico</i> studies helped us to gain valuable mechanistic insights, including the role of the hexafluoroisopropanol (HFIP) solvent, during C-H hydroxylation. The reactive intermediates, prior to the C-H activation, have been detected by spectroscopic techniques. Additionally, the C-O bond formation has been extended to <i>me ...[more]