Ontology highlight
ABSTRACT:
SUBMITTER: Font M
PROVIDER: S-EPMC6137440 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Chemical science 20180725 35
While several methods for the <i>ortho</i> selective arylation of fluoroarenes, <i>meta</i>-functionalisation has never been achieved. We report a new methodology, based on the traceless directing group relay concept, leading to the first <i>meta</i>-selective (hetero)arylation of fluoroarenes. In this strategy, CO<sub>2</sub> is introduced as a transient directing group, to control a Pd-catalysed arylation <i>meta</i> to the fluoro functionality, prior to its release in a sequential, one-pot fa ...[more]