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GPCRs and Signal Transducers: Interaction Stoichiometry.

ABSTRACT: Until the late 1990s, class A G protein-coupled receptors (GPCRs) were believed to function as monomers. Indirect evidence that they might internalize or even signal as dimers has emerged, along with proof that class C GPCRs are obligatory dimers. Crystal structures of GPCRs and their much larger binding partners were consistent with the idea that two receptors might engage a single G protein, GRK, or arrestin. However, recent biophysical, biochemical, and structural evidence invariably suggests that a single GPCR binds G proteins, GRKs, and arrestins. Here we review existing evidence of the stoichiometry of GPCR interactions with signal transducers and discuss potential biological roles of class A GPCR oligomers, including proposed homo- and heterodimers.

SUBMITTER: Gurevich VV

PROVIDER: S-EPMC6005764 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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GPCRs and Signal Transducers: Interaction Stoichiometry.

Gurevich Vsevolod V VV Gurevich Eugenia V EV

Trends in pharmacological sciences 20180505 7

Until the late 1990s, class A G protein-coupled receptors (GPCRs) were believed to function as monomers. Indirect evidence that they might internalize or even signal as dimers has emerged, along with proof that class C GPCRs are obligatory dimers. Crystal structures of GPCRs and their much larger binding partners were consistent with the idea that two receptors might engage a single G protein, GRK, or arrestin. However, recent biophysical, biochemical, and structural evidence invariably suggests ...[more]

PMID: 29739625

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