PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation.
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ABSTRACT:
SUBMITTER: Davis TB
PROVIDER: S-EPMC6006154 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation.
Davis Thomas B TB Yang Mingli M Schell Michael J MJ Wang Heiman H Ma Le L Pledger W Jack WJ Yeatman Timothy J TJ
Scientific reports 20180618 1
Colorectal cancer (CRC) growth and progression is frequently driven by RAS pathway activation through upstream growth factor receptor activation or through mutational activation of KRAS or BRAF. Here we describe an additional mechanism by which the RAS pathway may be modulated in CRC. PTPRS, a receptor-type protein tyrosine phosphatase, appears to regulate RAS pathway activation through ERK. PTPRS modulates ERK phosphorylation and subsequent translocation to the nucleus. Native mutations in PTPR ...[more]
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