Ontology highlight
ABSTRACT:
SUBMITTER: Rajasekharan SK
PROVIDER: S-EPMC6175908 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Rajasekharan Satish Kumar SK Kamalanathan Chakkaravarthi C Ravichandran Vinothkannan V Ray Arvind Kumar AK Satish Ann Susan AS Mohanvel Sucharitha Kannappan SK
Scientific reports 20181008 1
Mannich bases and its derivatives are regarded as supreme pharmacophores in therapeutics. The study investigates the antimycotic potential of Mannich bases, 1-((1H-benzimidazol-1-yl) methyl) urea (C1) and 1-((3-hydroxynapthalen-2-yl) methyl) thiourea (C2), against Candida albicans. Biofilm and hyphal inhibitory activities of the Mannich bases were tested by crystal violet quantification, fluorescence imaging cAMP rescue, qRT PCR, and by molecular docking analysis. The compounds inhibited the bio ...[more]