Ontology highlight
ABSTRACT:
SUBMITTER: Snoberger A
PROVIDER: S-EPMC6006169 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Snoberger Aaron A Brettrager Evan J EJ Smith David M DM
Nature communications 20180618 1
Protein degradation in all domains of life requires ATPases that unfold and inject proteins into compartmentalized proteolytic chambers. Proteasomal ATPases in eukaryotes and archaea contain poorly understood N-terminally conserved coiled-coil domains. In this study, we engineer disulfide crosslinks in the coiled-coils of the archaeal proteasomal ATPase (PAN) and report that its three identical coiled-coil domains can adopt three different conformations: (1) in-register and zipped, (2) in-regist ...[more]