Ontology highlight
ABSTRACT:
SUBMITTER: Mueller C
PROVIDER: S-EPMC6391972 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Mueller Carolin C Grossmann Tom N TN
Angewandte Chemie (International ed. in English) 20181128 52
The understanding of protein folding and assembly is of central importance for the design of proteins and enzymes with novel or improved functions. Minimalistic model systems, such as coiled-coils, provide an excellent platform to improve this understanding and to construct novel molecular devices. Along those lines, we designed a conformational switch that is composed of two coiled-coil forming peptides and a central binding epitope. In the absence of a binding partner, this switch adopts a hai ...[more]