Ontology highlight
ABSTRACT:
SUBMITTER: Fanning SW
PROVIDER: S-EPMC6006285 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Fanning S W SW Hodges-Gallagher L L Myles D C DC Sun R R Fowler C E CE Plant I N IN Green B D BD Harmon C L CL Greene G L GL Kushner P J PJ
Nature communications 20180618 1
Complex tissue-specific and cell-specific signaling by the estrogen receptor (ER) frequently leads to the development of resistance to endocrine therapy for breast cancer. Pure ER antagonists, which completely lack tissue-specific agonist activity, hold promise for preventing and treating endocrine resistance, however an absence of structural information hinders the development of novel candidates. Here we synthesize a small panel of benzopyrans with variable side chains to identify pure antiest ...[more]