Ontology highlight
ABSTRACT:
SUBMITTER: Moran SP
PROVIDER: S-EPMC6006294 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Moran Sean P SP Dickerson Jonathan W JW Cho Hyekyung P HP Xiang Zixiu Z Maksymetz James J Remke Daniel H DH Lv Xiaohui X Doyle Catherine A CA Rajan Deepa H DH Niswender Colleen M CM Engers Darren W DW Lindsley Craig W CW Rook Jerri M JM Conn P Jeffrey PJ
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20180314 8
Highly selective positive allosteric modulators (PAMs) of the M<sub>1</sub> subtype of muscarinic acetylcholine receptor have emerged as an exciting new approach for improving cognitive function in patients suffering from Alzheimer's disease and schizophrenia. However, excessive activation of M<sub>1</sub> is known to induce seizure activity and have actions in the prefrontal cortex (PFC) that could impair cognitive function. We now report a series of pharmacological, electrophysiological, and b ...[more]