Ontology highlight
ABSTRACT:
SUBMITTER: Cuypers MG
PROVIDER: S-EPMC6007404 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Cuypers Maxime G MG Robertson Rosanna M RM Knipling Leslie L Waddell M Brett MB Moon Kyung K Hinton Deborah M DM White Stephen W SW
Nucleic acids research 20180601 10
During infection, bacteriophage T4 produces the MotA transcription factor that redirects the host RNA polymerase to the expression of T4 middle genes. The C-terminal 'double-wing' domain of MotA binds specifically to the MotA box motif of middle T4 promoters. We report the crystal structure of this complex, which reveals a new mode of protein-DNA interaction. The domain binds DNA mostly via interactions with the DNA backbone, but the binding is enhanced in the specific cognate structure by addit ...[more]