Ontology highlight
ABSTRACT:
SUBMITTER: Hastie KM
PROVIDER: S-EPMC6007842 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Hastie Kathryn M KM Zandonatti Michelle A MA Kleinfelter Lara M LM Heinrich Megan L ML Rowland Megan M MM Chandran Kartik K Branco Luis M LM Robinson James E JE Garry Robert F RF Saphire Erica Ollmann EO
Science (New York, N.Y.) 20170601 6341
The arenavirus Lassa causes severe hemorrhagic fever and a significant disease burden in West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral surface and the critical target for antibody-mediated neutralization. Here we present the crystal structure of the trimeric, prefusion ectodomain of Lassa GP bound to a neutralizing antibody from a human survivor at 3.2-angstrom resolution. The antibody extensively anchors two monomers together at the base of the trimer ...[more]