Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee A
PROVIDER: S-EPMC9231621 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Banerjee Avik A Huang Jiachen J Rush Scott A SA Murray Jackelyn J Gingerich Aaron D AD Royer Fredejah F Hsieh Ching-Lin CL Tripp Ralph A RA McLellan Jason S JS Mousa Jarrod J JJ
Proceedings of the National Academy of Sciences of the United States of America 20220613 25
Human metapneumovirus (hMPV) is a leading cause of morbidity and hospitalization among children worldwide, however, no vaccines or therapeutics are currently available for hMPV disease prevention and treatment. The hMPV fusion (F) protein is the sole target of neutralizing antibodies. To map the immunodominant epitopes on the hMPV F protein, we isolated a panel of human monoclonal antibodies (mAbs), and the mAbs were assessed for binding avidity, neutralization potency, and epitope specificity. ...[more]